Clinical Trial
Study Details
Status
ACTIVE NOT RECRUITING
Study ID #
NCT06257485
Study Start
Primary Completion
Study Completion
Enrollment
476
Study Type
Observational
Interventions
99mTc-pyrophosphate Single Photon Emission Computed Tomography

All patients underwent 99mTc-pyrophosphate Single Photon Emission Computed Tomography and had a baseline echocardiogram

Primary Outcomes
Measure
ATTR-CM Diagnosis
Description

The number of patients who underwent a PYP SPECT scan diagnostic of ATTR-CM will be assessed and reported

Timeframe
During the index PYP scan within the study time frame parameters of the retrospective review (between 2014 and 2023)
Measure
Mortality
Description

The number of patients who died from all-cause mortality will be tabulated and reported

Timeframe
Within the study time frame parameters of the retrospective review (between 2014 and 2023)
Secondary Outcomes
Measure
Heart failure hospitalizations
Description

The number of patients admitted to the hospital with a primary diagnosis of heart failure will be tabulated and reported

Timeframe
Within the study time frame parameters of the retrospective review (between 2014 and 2023)
Measure
Total Hospitalizations
Description

The number of patients admitted to the hospital with any diagnosis will be tabulated and reported

Timeframe
Within the study time frame parameters of the retrospective review (between 2014 and 2023)
Summary

Transthyretin amyloid cardiomyopathy (ATTR-CM) is a commonly undiagnosed and potentially fatal disease. Contemporary studies on this condition often underrepresent the female gender and diverse patient populations. This registry retrospectively evaluated patients referred for 99mTc-pyrophosphate (PYP) Single Photon Emission Computed Tomography (SPECT) between 2014 and 2023 at Montefiore-Einstein in the Bronx. The patient population is racially and ethnically diverse and with a high proportion of females. Demographic, clinical (e.g. comorbidities), laboratory, echocardiographic, hospitalization, and mortality data were collected for each patient.

Conditions
Transthyretin Cardiac Amyloidosis
Transthyretin Amyloid Cardiomyopathy
Locations
Facility

Montefiore Health System
Bronx, NY 10467
United States

Eligibility Criteria

Inclusion Criteria:

* All adult patients referred for PYP SPECT at Montefiore Medical Center between 2014 and 2023

Exclusion Criteria:

* Did not have a transthoracic echocardiogram in our medical records

Eligibility Minimum Age
18 Years
Sexes Eligible for Study
ALL
Eligibility Std Ages
Adult
Older Adult
Study Population

All adult patients referred for PYP SPECT at Montefiore Medical Center between 2014 and 2023 who had a transthoracic echocardiogram in our medical records.