Clinical Trial
Study Details
Status
RECRUITING
Study ID #
NCT05521503
Study Start
Primary Completion
Study Completion
Enrollment
400
Study Type
Observational
Primary Outcomes
Measure
Discover and quantify the concentration of novel diagnostic and prognostic biomarkers
Description

Use biospecimens procured from patients with cardiac amyloidosis to identify diagnostic surrogate biomarkers using discovery proteomics. The serum levels will be compared between confirmed ATTR and non-ATTR heart failure patients and a diagnostic threshold will be established.

Timeframe
12/21/2021-12/31/2027
Summary

Use samples procured from patients to improve understanding of molecular, cellular, and tissue-level processes produced by cardiac amyloidosis and therapeutic interventions.

Description

This is a prospective study enrolling patients referred for or undergoing cardiac amyloidosis or cardiovascular treatment at the University of Kentucky. The study aims to facilitate the discovery of novel diagnostic biomarkers and therapeutic targets and improve the pathophysiological understanding of cardiac amyloidosis.

Conditions
Cardiac Amyloidosis
Study Contact
Name
Andrew R Kolodziej, MD
Role
Contact
Phone
(859) 562-0902
Email
andrew.kolodziej@uky.edu
Name
Jennifer Isaacs, MS, MS
Role
Contact
Phone
(859) 323-4738
Email
jennifer.isaacs@uky.edu
Facility

University of Kentucky
Lexington, KY 40536
United States

Contacts
Study Contact
Name
Andrew Kolodziej, MD
Role
Principal Investigator
Eligibility Criteria

Inclusion Criteria:

* All patients undergoing treatment for cardiac amyloidosis or receiving a right heart catheterization who are at least 18 years of age.

Exclusion Criteria:

* Patients without a cardiovascular or amyloidosis diagnosis, under 18 years of age.

Eligibility Minimum Age
18 Years
Sexes Eligible for Study
ALL
Eligibility Std Ages
Adult
Older Adult
Study Population

All patients referred for or undergoing treatment for cardiac amyloidosis or receiving a right heart catheterization who are at least 18 years of age.

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